In the past few years, the function and nutritional value of these nutrients have been investigated enormously. It was found out that BioBran MGN-3 serves a significant role in anti-inflammatory reactions, reduction in plasma lipid effect, and anti-cancer activities.
Furthermore, it has been found that BioBran MGN-3 is used for the treatment of cancer patients. Several studies have focused on the critical part of this food supplement in the ruling of oxidative response, immune functioning, inflammatory reactions, tumor suppression, and cholesterol metabolism.
Anticancer Properties of BioBran MGN-3 through Its Mode of Action
Reduce Anti-Inflammatory Reaction
The most significant factor behind tumor suppression is inflammation that can give way to the development of cancer cells. Inflammation is also responsible for the proliferation of cancer cells and the promotion of angiogenesis.
Thus reducing this inflammation can be used as a helpful target for treating cancer since BioBran MGN-3 is rich in enzymatic extracts and protein hydrolysate so it can easily mitigate the secretion of inflammation in the body.
The gamma-oryzanol present in BioBran MGN-3 has excellent anti-inflammatory properties, and it can repress tumor growth in the pancreas by decreasing NF-KB-facilitated inflammatory settings. The presence of dextran sodium sulfate can also overpower the penetration of inflammatory cells and the discharge of inflammatory factors inside the body.
Cell Cycle Arrest
Cell cycle proteins that are abnormal can lead to the proliferation of uncontrolled cells inside the body. It can lead to the progression of cancer. Therefore, BioBran MGN-3 can be used to provide cell cycle blockers that are ideal for conventional cancer treatment. Tricin (flavone) is a significant component of this product and has the potential to arrest cancer cells at line MDA-MB-468 during the G2/M phase. Tricin can also reduce the volume of cancerous cells.
Gamma Tocotrienol present in BioBran MGN-3 can inhibit adenocarcinomas and its proliferation inside the cells during the G0/G1 phase while Momilactone B which is a terpenoid phytoalexin can produce its anti-cancer properties after consumption by targeting leukemia cells by arresting them during G1 phase. Phytic acid also is known as inositol hexakisphosphate can carry out cell cycle arrest at the G0 phase and sometimes at the G1 phase.
Stimulating Cell Apoptosis
Another primary reason for cancer cell development is the non-regulation of cell apoptosis. Water-based extracts added in BioBran MGN-3 can induce cell apoptosis. For example, Phytic acid can have a pro-apoptotic effect on cancer cells by the regulation of Bcl-xl and Bax protein expression. It can also induce the apoptosis of the cells in the liver through the upregulation of the manifestation of the anti-apoptotic gene, i.e., Bcl-2.
A phenolic compound, i.e., Cycloartenyl Ferulate present in BioBran MGN-3 can enhance the activity of DR4 and DR5 (death receptors) which can suppress the anti-apoptotic expression of Bcl-2, the elevation of pro-apoptotic Bak, and apoptosis of cancer cells. In general, several other constituents and components of this supplement can be used to support the apoptosis of cancer cells through augmentation of pro-apoptotic protein expression and repression of anti-apoptotic protein expression.